Cat#: HRD100028 Host: Rabbit Clonality: Polyclonal
Immunogen: Recombinant Protein Isotype: IgG
Tested Reacted Species: Human, Mouse,Rat, Storage: -20°C
Recommended Application: ELISA, WB,IP,IHC Size:100ul/200ul
Background: Human neutrophil alpha-defensins （also designated HNPs） are small, cat-ionic,cysteine-rich
antimicrobial proteins that play important roles in innate immunity against infectious microbes such as
bacteria, fungi and enveloped viruses. Alpha-defensins are synthesized as inactive precursors and are
acti-vated by proteolytic cleavage by MMP-7. Paneth cells in small intestinal crypts secrete the
alpha-defensins, which are also termed cryptidins in mice.The cryptidin-4 gene is unique among the Paneth
cell alpha defensins in that it is inactive in the duodenum, but expressed at maximal levels in the distal
small bowel.
Specificity: 1.Anti-α-defensin 1，2，3 is a rabbit polyclonal antibody unconjugated;
2.Specific forα-defensin 1，2，3 of human, mouse, rat
3.Affinity chromatography purification, purity :>95%
4.Mol wt: 12kDa
5.This antibody has been selected for its ability to recognize
humanα-defensin 1，2，3 in immunohistochemiscal staining and
western blotting, non cross-reactive with other members of
the family.
6. epitope mapping corresponding to amino acids ofα-defensin 1，2，3
of human, mouse,rat
Application : Western blotting 1:100-500
Immunohistochemistry 1:100-500
ELISA 1:500-1000
Optimal working dilutions must be determined by the end user