Anti-GCR Polyclonal Antibody
應用 WB
稀釋比例WB 1:3000.
交叉反應Human

產(chǎn)品型號：K101529P

更新時間：2022-08-15

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Anti-GCR Polyclonal Antibody

英文名稱	Anti-GCR Polyclonal Antibody
宿主	Rabbit
別名	GCCR;GCR;GCRST;GR;GRL
應用	WB
稀釋比例	WB 1:3000.
交叉反應	Human
蛋白分子量	86kDa
Gene ID	2908
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human GCR
性狀	液體
Public Immunogen Range	A synthetic peptide of human GCR
Subcellular Locations	Cytoplasm Mitochondrion Nucleus Nucleus
Swiss Prot	P04150
克隆類型	Polyclonal Antibody
背景資料	Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth.