Anti-LAMP1 Polyclonal Antibody
應(yīng)用 WB IHC
稀釋比例WB 1:2000-5000.IHC 1:50-200.
交叉反應(yīng)Human Mouse Rat

產(chǎn)品型號：K106533P

更新時間：2022-08-15

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Anti-LAMP1 Polyclonal Antibody

英文名稱	Anti-LAMP1 Polyclonal Antibody
宿主	Rabbit
別名	CD107a;LAMPA;LGP120;lgpA;OTTHUMP00000040663
應(yīng)用	WB IHC
稀釋比例	WB 1:2000-5000.IHC 1:50-200.
交叉反應(yīng)	Human Mouse Rat
蛋白分子量	40kDa
Gene ID	3916
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human LAMP1
性狀	液體
Public Immunogen Range	A synthetic peptide of human LAMP1
Subcellular Locations	Cell membrane Endosome membrane Late endosome Lysosome membrane Single-pass type I membrane protein
Swiss Prot	P11279
克隆類型	Polyclonal Antibody
背景資料	Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.