Anti-PTEN Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:3000.
交叉反應(yīng)Human Mouse Rat

產(chǎn)品型號：K106537P

更新時間：2022-08-15

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Anti-PTEN Polyclonal Antibody

英文名稱	Anti-PTEN Polyclonal Antibody
宿主	Rabbit
別名	10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;PTENbeta;TEP1
應(yīng)用	WB
稀釋比例	WB 1:3000.
交叉反應(yīng)	Human Mouse Rat
蛋白分子量	47kDa
Gene ID	5728
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human PTEN
性狀	液體
Public Immunogen Range	A synthetic peptide of human PTEN
Subcellular Locations	Cytoplasm Nucleus PML body Secreted
Swiss Prot	P60484
克隆類型	Polyclonal Antibody
背景資料	This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.