Anti-AIF Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:500-2000.
交叉反應(yīng)Human Mouse Rat

產(chǎn)品型號(hào)：K106588P

更新時(shí)間：2022-08-15

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Anti-AIF Polyclonal Antibody

英文名稱(chēng)	Anti-AIF Polyclonal Antibody
宿主	Rabbit
別名	AIFM1;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8
應(yīng)用	WB
稀釋比例	WB 1:500-2000.
交叉反應(yīng)	Human Mouse Rat
蛋白分子量	66kDa
Gene ID	9131
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	Recombinant protein of human AIF
性狀	液體
Public Immunogen Range	Recombinant protein of human AIF
Subcellular Locations	Cytoplasm
Swiss Prot	O95831
克隆類(lèi)型	Polyclonal Antibody
背景資料	Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.