Anti-BAX Polyclonal Antibody
應(yīng)用 IHC
稀釋比例IHC 1:50-200.
交叉反應(yīng)Human

產(chǎn)品型號：K106624P

更新時間：2022-08-15

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Anti-BAX Polyclonal Antibody

英文名稱	Anti-BAX Polyclonal Antibody
宿主	Rabbit
別名	Bcl2-L-4;Bax-protein;BAX_HUMAN;BAXA
應(yīng)用	IHC
稀釋比例	IHC 1:50-200.
交叉反應(yīng)	Human
蛋白分子量	21kDa
Gene ID	581
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human BAX
性狀	液體
Public Immunogen Range	A synthetic peptide of human BAX
Subcellular Locations	Cytoplasm Cell membrane
Swiss Prot	Q07812
克隆類型	Polyclonal Antibody
背景資料	Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.7